TANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning.

TANGO6 orchestrates transcription and translation by shuttling between nucleus and cytoplasm, regulating essential genes and protein synthesis during cell stress.

• Why it matters: Understanding how cells coordinate gene expression and protein production is vital for insights into cell survival and stress responses, yet the mechanisms remain unclear.
• What they did: The study used molecular and cellular approaches to show that TANGO6 binds gene promoters with RNA polymerase II in the nucleus and associates with polysomes in the cytoplasm, with its localization changing under stress.
• The result: TANGO6's nucleocytoplasmic movement enables dynamic control of the proteome, supporting cell viability and adaptation, highlighting its central role in maintaining cellular homeostasis and stress resilience.