Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer's disease.

Mapping dynamic Alzheimer's disease progression reveals four distinct biological stages with specific molecular and cognitive trajectories.

• Why it matters: Understanding the disease's dynamic transitions is crucial for optimizing treatment timing, as static biomarker categories may overlook critical disease processes.
• What they did: The study used neuroimaging brain network topology and proteomic analyses to identify four reproducible subgroups representing sequential molecular and pathological stages in Alzheimer's disease.
• The result: This framework enables more precise disease stratification and suggests that targeting amyloid in the initiation stage may slow cognitive decline, improving therapeutic strategies.