Mito-nuclear incompatibility disrupts ACOX1/ACOX3-mediated mitochondria-peroxisome metabolic coordination in black soldier flies.

Mito-nuclear incompatibility in black soldier flies disrupts mitochondrial and peroxisomal metabolism, reducing ACOX1/ACOX3 activity and impairing organismal fitness.

• Why it matters: Understanding how genomic incompatibilities affect cellular organelle coordination is crucial for insights into metabolic diseases and hybrid breakdown, especially in insects.
• What they did: Researchers introduced heterologous mitochondrial genomes into a common nuclear background in Hermetia illucens, then combined genomic, transcriptomic, metabolomic, and functional analyses to study effects.
• The result: Disruption of mitochondrial and peroxisomal functions led to energy deficits and developmental delays, with restoring ACOX expression partially rescuing lipid metabolism and organismal health.