bioETH-PRS: confidential polygenic risk scoring with smart contracts on an FHE-enabled blockchain.

bioETH-PRS enables confidential polygenic risk scoring entirely within encrypted data using smart contracts on an fhEVM-enabled blockchain, ensuring privacy and transparency.

• Why it matters: Protecting sensitive genetic data during risk score calculations is critical to prevent exposure and maintain user trust, addressing limitations of existing homomorphic encryption methods that rely on trusted evaluators.
• What they did: The protocol employs integer-exact encrypted arithmetic and a four-contract architecture to compute PRS scores in the encrypted domain, supporting both encrypted input storage and streaming modes, with a release oracle for risk categorization.
• The result: Prototype testing indicates linear cost growth with variant count on a public testnet, demonstrating potential practicality for moderate-sized models while redistributing trust to blockchain components.