PCBP2 facilitates miR-93-5p-mediated repression of GDF11 in HCC cell lines.
- Open access
PCBP2 enhances miR-93-5p-mediated repression of GDF11, a tumor suppressor, promoting proliferation and invasion in hepatocellular carcinoma cells.
- Why it matters: Understanding how GDF11 is downregulated in HCC is crucial, as its suppression contributes to tumor progression, and targeting this pathway could offer new therapeutic strategies.
- What they did: The study investigated the role of the miR-106b-25 cluster, especially miR-93-5p, and identified PCBP2 as an RNA-binding protein that facilitates miR-93-5p's repression of GDF11 through binding near its target site in the 3' UTR.
- The result: Inhibiting miR-93-5p restored GDF11 levels and reduced tumor cell behaviors, while manipulating PCBP2 levels modulated this repression, highlighting potential targets for HCC treatment.