An integrated lifestyle intervention for mitigation of adverse effects associated with androgen deprivation therapy for prostate cancer (STAMINA): a multicentre, randomised trial.
The STAMINA lifestyle intervention significantly improved quality of life and fatigue in men with prostate cancer on ADT, with FACT-P scores increasing by 4.5 points and FACIT-F by 1.9 points.
- Why it matters: Adverse effects from androgen deprivation therapy (ADT) negatively impact patients' well-being, yet supervised exercise is rarely integrated into standard care, leaving a gap in supportive treatment options.
- What they did: A multicentre, randomized trial involving 700 men across 15 UK NHS trusts tested a 12-month supervised exercise, dietary, and behavioral support program versus usual care, measuring outcomes at 12 months.
- The result: The intervention proved superior in improving quality of life and fatigue, demonstrating its feasibility for NHS implementation and providing a clear approach for clinicians to mitigate ADT-related adverse effects.