Targeted left ventricular lead placement in biventricular pacing for heart failure: a national, multicentre, double-blind, randomised controlled trial in Denmark.
Targeted left ventricular lead placement at the site of latest electrical activation did not reduce death or heart failure hospitalisation in heart failure patients with wide QRS.
- Why it matters: Optimizing lead placement could improve outcomes in biventricular pacing for heart failure, addressing variability in patient responses and potentially saving lives.
- What they did: A national, multicentre, double-blind, randomized trial involving 1000 patients compared targeted lead placement at the latest activation site versus conventional posterolateral placement, measuring death or first unplanned heart failure hospitalisation.
- The result: The study found no significant difference in primary outcomes between groups, with similar complication rates, indicating that targeted placement does not improve clinical endpoints in this patient population.