Aetiology, management, and outcomes of acute heart failure in 17 African countries (THESUS-HF II): a prospective, multicentre, observational cohort study.

Acute heart failure in Africa shows a median age of 56 years with an 11.1% 30-day and 20.6% 180-day mortality rate, highlighting significant health challenges.

• Why it matters: Understanding the causes, treatment, and outcomes of acute heart failure in Africa is crucial to improve patient care and reduce mortality in a relatively young population.
• What they did: A prospective, multicentre cohort study enrolled 1,578 adults across 17 countries, assessing presentation rates, etiologies, treatments, and 180-day outcomes through clinical and follow-up data.
• The result: Findings reveal shifting etiologies, high mortality rates, and suboptimal target dosing of therapies, emphasizing the need for better prevention, access to care, and guideline adherence to improve outcomes.