Entangled dual-site migration through boracycle rearrangement.

Entangled dual-site migration along eight carbons achieved with borinane rearrangement, enabling precise control over regio- and diastereoselectivity at two distant sites.

• Why it matters: Controlling simultaneous migration of two remote sites is challenging due to the complexity of chemoselectivity and stereoselectivity, limiting synthetic options for complex molecules.
• What they did: The authors developed a borinane rearrangement process that moves a borinane ring along a carbon chain, traversing up to eight carbons and controlling two migration sites with high selectivity.
• The result: This method produces versatile boracyclic products that serve as building blocks for diverse (hetero)cycles and multi-site modifications, broadening the scope of complex molecule synthesis.