Ovarian aging and systemic health: Mechanisms and emerging intervention strategies.
Ovarian aging drives systemic aging through cellular defects and hormonal decline, with interventions showing potential to extend healthspan and preserve fertility.
- Why it matters: Understanding how ovarian aging influences overall health is crucial because it may contribute to age-related diseases and multimorbidity in women, yet the mechanisms remain incompletely understood.
- What they did: The review discusses ovarian cellular defects such as genomic instability, epigenetic changes, and mitochondrial damage, along with emerging interventions like senolytics, metabolic reprogramming, and regenerative therapies.
- The result: Targeting ovarian aging could prevent systemic decline, improve healthspan, and address female multimorbidity, highlighting the importance of ovary-focused strategies for healthy aging.