Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism.
- Open access
Hepatic ACSF3 regulates rhythmic lysine-malonylation and daily liver metabolism, with knockdown disrupting glucose and lipid homeostasis in mice.
- Why it matters: Understanding how circadian and feeding cues control liver metabolism is crucial for addressing metabolic diseases linked to circadian disruption.
- What they did: Researchers used multi-omics profiling and knockdown experiments to show that ACSF3 oscillates with feeding schedules, influencing lysine-malonylation and metabolic pathways in the liver.
- The result: Disruption of ACSF3 altered glucose and lipid metabolism, shifting lipid oxidation pathways and increasing autophagy, revealing ACSF3 as a key regulator of diurnal hepatic metabolic rhythms.