Evolutionary Antifragile Therapy Is a Treatment Strategy to Suppress Drug Resistance by Exploiting Dose-Response Convexity.

Convex dose-response curves predict that continuous treatment outperforms uneven dosing in suppressing tumor resistance, supporting an antifragile therapy approach.

• Why it matters: Understanding how treatment fluctuations influence tumor evolution is crucial for developing strategies that prevent resistance and improve therapy outcomes.
• What they did: The study analyzed dose-response convexity in tumor cells, tested different dosing schedules in vivo, and validated that convexity predicts response to treatment fluctuations.
• The result: Findings show that leveraging dose-response curvature can optimize treatment schedules to maximize tumor response and delay resistance, advancing the concept of evolutionary antifragile therapy.