PTMExplorer: A Multi-Dimensional Integrative Visualization Platform for Protein Post-Translational Modification Function and Structure
- Open access
PTMExplorer enables multi-dimensional visualization of protein PTMs, integrating structural, functional, and disease data across eight model organisms, enhancing biological insights.
- Why it matters: Understanding PTM functions is essential for linking large-scale proteomics data to mechanisms underlying health and disease, but current tools lack comprehensive multi-dimensional context.
- What they did: The platform combines three modules—PTM Inspector, PTM 3D Locator, and PTM Overview—along with disease databases, supporting user-uploaded data and detailed annotations, demonstrated through hepatocellular carcinoma analysis.
- The result: PTMExplorer facilitates rapid assessment of PTM significance, aids biomarker discovery, and uncovers modification coordination, advancing research in proteomics and disease mechanisms.