bioRxiv · 6 Sept 2026 · Preprint · Open access

Glucocorticoid rhythm disruption drives hyperinsulinaemia in mice through beta cell glucocorticoid receptor signalling

Wilson, Arzeno + 4 more

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Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity.
New England Journal of Medicine · 29 Sept 2026 · Journal Article
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An amygdaloreticular pathway promotes motor programs of ingestion.
Cell Reports · 22 Sept 2026 · Journal Article
Activation of the amygdaloreticular pathway induces overeating and ingestion-like behaviors regardless of metabolic need or palatability cues.
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Disrupted glucocorticoid rhythms selectively induce severe skeletal muscle insulin resistance and uncouple obesity from hepatic steatosis.
Cell Reports · 22 Sept 2026 · Journal Article
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