A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration.

A Crohn's disease risk allele linked to increased SKAP2 expression in T cells modulates adhesion and migration balance.

• Why it matters: Understanding genetic regulators of T cell functions can reveal mechanisms underlying autoimmune disorders like Crohn's disease.
• What they did: The study analyzed T cells from individuals with different SKAP2 alleles and engineered cells to alter SKAP2 levels, examining its role in adhesion and migration.
• The result: Findings show SKAP2 promotes T cell adhesion and restrains migration, with its cleavage upon activation enabling a migratory program, highlighting its role in T cell regulation.