Turning cold tumors hot: Strategies to enhance antitumor immunity.

Combining multiple strategies to convert cold tumors into hot tumors is necessary for durable antitumor immune responses.

• Why it matters: Cold tumors lack immune infiltration and immune responses, representing a major challenge for effective cancer immunotherapy and limiting patient benefits.
• What they did: The review discusses emerging approaches that enhance tumor antigenicity, promote immune priming, induce immunogenic cell death, improve T cell trafficking, reverse immunosuppression, and remodel the tumor microenvironment, emphasizing the need for integrated therapies.
• The result: Current evidence indicates that no single mechanism suffices for cold-to-hot tumor conversion, suggesting that multi-layered, combined interventions are essential to overcome immune resistance and improve therapeutic outcomes.