Subverting colonization resistance: Salmonella pathogenesis at the interface of microbiota, metabolism and inflammasome.

Salmonella overcomes colonization resistance by disrupting microbiota, inducing inflammation, and damaging the intestinal barrier, promoting chronic infection.

• Why it matters: Understanding how Salmonella subverts gut defenses is crucial for developing effective treatments against persistent infections and maintaining intestinal health.
• What they did: The review synthesizes molecular mechanisms involving microbiota disruption, inflammasome activation, and metabolic imbalance, highlighting how Salmonella exploits these processes.
• The result: Microbiota-based strategies such as probiotics, antimicrobials, and phage therapy are proposed as promising approaches to restore gut homeostasis and counteract Salmonella infection.